Scientists reported a significant reduction in artery-clogging cholesterol following a genetic modification. The treatment, which involved modifying a key gene using CRISPR-Cas9, reduced cholesterol by approximately 50% for a year without adverse effects in four patients. These patients received the highest dose of the experimental treatment as part of a pilot study.

The study, published in The New England Journal of Medicine, involved 15 patients with dangerously high cholesterol levels who did not respond to medication. The goal of the research was to evaluate the safety of five different doses of a genetic modification infusion.

Further details on the study and its findings are available from the original source, which provides more information on this experimental treatment.